mcp server
nullary
Negative results intelligence for drug discovery — query measured failures via MCP.
Description as published by the maintainer. Source
- version 1.0.1
- archived
archived — The linked repository returns 404. It was deleted, renamed or made private.
What this server can do
35 functions, named and described by the server itself. Parameter names are shown because they say more about what a function does than its name usually does.
get_compound(tier, limit, offset, chembl_id, inchi_key, pubchem_cid)- A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.
get_coverage- Per-modality and per-source coverage stats (honest Phase-1 numbers).
get_finding_provenance(id)- Full provenance + detail for a single finding by id. Required: id.
get_model_card(target)- Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533). Required: target.
get_target_landscape(target)- Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533). Required: target.
list_models- Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
list_top_targets(limit, family)- Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).
search_adc_linker_failures(tier, limit, offset, target, outcome, compound)- ADC failures attributed to linker chemistry.
search_admet_failures(tier, limit, offset, target, outcome, compound)- Small-molecule ADMET failures.
search_admet_failures_all_modalities(tier, limit, offset, target, outcome, compound)- ADMET failures across ALL modalities.
search_ancestry_specific_failures(tier, limit, offset, target, outcome, compound)- Ancestry-specific CRISPR failures.
search_bispecific_format_failures(tier, limit, offset, target, outcome, compound)- Bispecific format/engineering failures.
search_developability_failures(tier, limit, offset, target, outcome, compound)- Antibody developability failures.
search_drug_drug_interaction_failures(tier, limit, offset, outcome, compound)- Drug-drug interaction failures.
search_failed_adcs(tier, limit, offset, target, outcome, compound)- ADCs that failed at any stage.
search_failed_bispecifics(tier, limit, offset, target, outcome, compound)- Bispecifics that failed at any stage.
search_failed_clinical_antibodies(tier, limit, offset, target, outcome, compound)- Discontinued/terminated clinical antibodies.
search_failed_essentiality_screens(tier, limit, offset, target, outcome, compound)- Non-dependency / failed essentiality screens.
search_failed_guides(tier, limit, offset, target, outcome, compound)- Failed/ineffective CRISPR guides.
search_failed_oligonucleotides(tier, limit, offset, target, outcome, compound)- ASOs/siRNAs that failed engagement/developability.
search_failed_peptide_therapeutics(tier, limit, offset, target, outcome, compound)- Failed peptide therapeutics.
search_failed_protacs(tier, limit, offset, target, outcome, compound)- PROTACs that failed degradation/ternary/permeability.
search_failed_replications(tier, limit, offset, target, outcome, compound)- Findings that failed to replicate.
search_failed_selectivity(tier, limit, offset, target, outcome, compound)- Small molecules that failed selectivity.
search_failed_vaccines(tier, limit, offset, target, outcome, indication)- Failed/terminated vaccines (by pathogen/indication).
search_inactive_compounds(tier, limit, offset, target, outcome, compound)- Inactive small-molecule compound-target pairs.
search_indication_history(tier, limit, offset, indication)- ALL failed approaches for an indication across every modality. Required: indication.
search_mechanism_failures(tier, limit, offset, target, outcome, compound)- Approaches that failed for a mechanism (by target).
search_oligo_delivery_failures(tier, limit, offset, target, outcome, compound)- Oligonucleotide delivery failures.
search_pathogen_history(tier, limit, offset, pathogen)- Vaccine + antimicrobial + antibody failures for a pathogen. Required: pathogen.
search_peptide_stability_issues(tier, limit, offset, target, outcome, compound)- Peptide stability/half-life failures.
search_protac_e3_issues(tier, limit, offset, target, outcome, compound)- PROTAC E3-ligase recruitment / ternary failures.
search_safety_failures(tier, limit, offset, target, outcome, compound)- Clinical/preclinical safety failures across modalities.
search_target_history(tier, limit, offset, target)- ALL failed approaches against a target across every modality. Required: target.
search_vaccine_immunogenicity_failures(tier, limit, offset, target, outcome, compound)- Failed vaccine immunogen designs.
Last successful function declaration observed on . Source: https://mcp.nullary.ai/mcp. We list what the server declared; we do not call any of these functions.
Endpoint status observed on . Source: https://mcp.nullary.ai/mcp.
Signals
These are separate measurements of different things. They are deliberately not combined into one score, because a popularity number that mixes website traffic with saves and stars cannot be checked or acted on.
| Signal | Value | What it measures | Window | Observed | Source |
|---|---|---|---|---|---|
| Latest published version | 1.0.1 | Latest version string the maintainer published to the registry. | as of fetch | Model Context Protocol | |
| Registry record last updated | 2026-05-25 | When the registry record was last updated by its maintainer. | point in time | Model Context Protocol | |
| First listed in the MCP Registry | 2026-05-25 | Date this server was first published to the official MCP Registry. Not a usage or quality measure. | point in time | Model Context Protocol | |
| repository status | not_found | GitHub returned 404 for the repository the maintainer listed. The project was deleted, renamed or made private, so the listing points at nothing. | as of fetch | GitHub | |
| mcp tools declared | 35 tools | Number of functions the server itself declared when asked to list them. This is what the server offers an agent, not a measure of how well any of them work. | as of probe | mcp.nullary.ai | |
| mcp endpoint status | ok | The server listed 35 functions when asked. | as of probe | mcp.nullary.ai |
Where to get it
This record as data
Every field on this page, with its source and observation date, is in the catalog JSON. Fetch the whole kind at once instead of parsing this HTML.
GET /api/v1/entries/mcp_server.json